在线双极双喷雾器用于电荷状态的降低和复杂合成聚合物的特性
John R Stutzman1, Paul D Hutchins1, Ryan M Bain1
1Analytical Sciences, Dow Inc., Midland, Michigan 48640, United States.
Journal of the American Society for Mass Spectrometry
|December 6, 2023
概括
双极双喷雾与液体染色学质谱学 (LC/MS) 结合,有效地降低了合成聚合物的电荷状态. 这种先进的技术简化了复杂的混合物分析,并识别了传统方法遗漏的杂质.
科学领域:
- 分析化学 分析化学
- 聚合物科学 聚合物科学
背景情况:
- 液体染色学-质谱学 (LC/MS) 对于分析复杂混合物,特别是合成聚合物至关重要.
- 减电质谱法 (CR/MS) 通过简化质谱来增强分析.
- 双极双喷是一种新的电荷操纵技术,用于减少离子电荷状态.
研究的目的:
- 调查双极双喷雾对使用LC/MS.合成聚合物的电荷减轻的有效性.
- 展示首个在线应用双喷雾用于LC/MS的电荷降低.
- 改进复杂聚合物混合物的表征和识别低水平杂质.
主要方法:
- 结合液体色谱与双极双喷雾和质谱 (LC/MS).
- 使用两个相反电荷的电喷射发射器来合液滴并减少离子电荷.
- 分析聚乙烯甘醇 (PEG) 7.2K和末端组修改的PEG 10K.
主要成果:
- 双极双喷雾使PEG 7.2K的平均充电状态从8.2+降低到4.4+.
- 使用双喷雾的LC/MS成功地在终端组修饰的PEG 10K中识别出低水平的杂质 (基化PEG,PEG单胺).
- 这种方法检测了标准LC/MS和直接输液双喷雾所遗漏的杂质.
结论:
- 双极双喷雾器有效地集成到LC/MS中,以在线降低收费.
- 该技术简化了光谱,解压缩了m/z轴,减少了复杂性.
- 这种方法提高了数据的解释,并使得在聚合物混合物中识别以前未被检测到的成分成为可能.
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