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早期和晚期的抗肥胖药物持久性:一个回顾性队列研究
Hamlet Gasoyan1,2, Elizabeth R Pfoh1,2, Rebecca Schulte3
1Center for Value-Based Care Research, Department of Internal Medicine and Geriatrics, Primary Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Obesity (Silver Spring, Md.)
|December 6, 2023
概括
患者在12个月内服用抗肥胖药物 (AOM) 的持久性为19%,而塞马格卢类药物显示最高的1年持久性. 在6个月体重减轻显著影响长期AOM坚持.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肥胖医学 肥胖医学
- 现实世界的证据.
背景情况:
- 抗肥胖药物 (AOM) 对于控制肥胖,一种复杂的慢性疾病至关重要.
- 了解患者长期遵守AOM对于有效的体重管理策略至关重要.
研究的目的:
- 为了确定初始抗肥胖药物 (AOM) 患者的持续率,在3,6个月和12个月内填充.
- 为了确定与12个月AOM持久性相关的因素.
主要方法:
- 从2015年1月到2023年7月使用电子健康记录的回顾性队列研究.
- 包括成人 (BMI ≥30 kg/m2) 在2015年至2022年之间填写初始AOM处方.
- 分析了3,6和12个月的持续性以及影响12个月持续性的因素.
主要成果:
- 包括1911名患者,基线BMI中位数为38.
- 对AOM的12个月持续率为19%.
- 塞马格卢提德的持续时间在1年内是最高的 (40%). 一年持久性更高的几率与塞马格卢提德 (AOR=4.26) 和6个月后的体重减轻相关 (体重减轻的1%增加与持久性增加的6%的几率相关). 与芬特明-托皮拉相比,纳尔特雷-布普罗与更低的几率 (AOR=0.68) 相关.
结论:
- 对抗肥胖药物的长期持续性因药物而异.
- 在6个月内减肥是持续服药的关键预测因素.
- 个性化治疗策略,考虑到药物的有效性和患者特异性的减肥是至关重要的.
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