休息状态功能连接与中风后自觉受损相关
Jeffrey M Kenzie1,2, Deepthi Rajashekar1, Bradley G Goodyear1,2,3,4
1Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Human brain mapping
|December 6, 2023
概括
卒中幸存者经常经历自身感知缺陷. 这项研究揭示了中风患者的大脑连接的改变,确定了潜在治疗点的关键领域,以改善四肢位置感觉恢复.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 医疗成像医学成像
背景情况:
- 自身感知缺陷影响大约50%的中风幸存者,阻碍康复和恢复.
- 了解这些缺陷的神经基础对于有效的治疗策略至关重要.
- 目前的知识差距限制了旨在恢复自身感觉的干预措施的有效性.
研究的目的:
- 为了研究功能性大脑网络连接的变化,与中风后的自身感知缺陷相关.
- 确定特定的大脑区域和网络对于中风幸存者自身感知至关重要.
- 探索功能连接性评估对预后和治疗向的潜力.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 对30名中风参与者和30名年龄匹配的健康对照进行.
- 使用Kinarm机器人外骨架来评估自身感知障碍.
- 功能连接性分析的重点是涉及自觉的脑区域,包括补充运动区域,上边缘环,主要体感皮质和部部区域.
主要成果:
- 与对照人群相比,中风患者在补充运动区域和上边脊髓中表现出功能连接性降低.
- 主体体感官皮层和状部区域内的连接与自感功能有显著的关联.
- 受影响半球的头顶叶表现为中风后自身感受的关键网络节点.
结论:
- 功能连接的改变,特别是在头顶叶内,与中风后的自身感知缺陷有关.
- 评估这些地区的功能连接可能有助于预测中风恢复结果.
- 这些发现表明神经刺激疗法的潜在目标是加强中风康复和自身感知恢复.
相关概念视频
The Parasympathetic Nervous System
Overview
Functional Brain Systems: Reticular Formation
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Autonomic Nervous System
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
Fatigue
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
General State of Stress
The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Stress Response System
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's initial...
Alarm stage
In the alarm stage, the body's initial...


