如今,炎症性关节炎患者的心血管疾病风险仍然大幅增加
Reinder Raadsen1, Romy Hansildaar1, Lianne C Pouw2
1Amsterdam Rheumatology and Immunology Center, Amsterdam, Noord-Holland, The Netherlands.
患有炎症性关节炎 (IA) 的患者由于传统风险因素,心血管疾病 (CVD) 风险更高. 改善这些因素的管理对于类风湿性关节炎 (RA),牛皮性关节炎 (PsA) 和轴性脊髓关节炎 (SpA) 患者至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 炎症性关节炎 (IA),包括类风湿性关节炎 (RA),牛皮性关节炎 (PsA) 和轴性脊髓关节炎 (SpA),与心血管疾病 (CVD) 的患病率增加有关.
- 传统的心血管风险因素通常在IA患者中升高,这有助于他们的心血管疾病风险增加.
- 了解IA,传统风险因素和心血管疾病之间的相互作用对于有效的患者管理至关重要.
研究的目的:
- 评估目前的心血管疾病风险和相关风险因素的患病率在被诊断为类风湿性关节炎 (RA),牛皮性关节炎 (PsA) 和轴性脊椎关节炎 (SpA) 的患者.
- 将炎症性关节炎 (IA) 患者的心血管风险和风险因子患病率与健康个体的对照组进行比较.
主要方法:
- 一项前性队列研究,涉及2050名IA患者 (1308名RA,356名PsA,386名SpA) 和939名对照.
- 使用问卷来收集有关之前心血管事件和风险因素的数据.
- 使用后勤回归模型来评估心血管风险和患病率的计算几率比率 (ORs).
主要成果:
- 与对照组相比,IA患者的传统心血管风险因素显著增加.
- 与对照组相比,RA (OR 1.61) 和PsA (OR 2.12) 患者的心血管疾病 (CVD) 几率比率增加;在SpA (OR 1.43) 中观察到趋势.
- 在对传统风险因素进行调整后,对于RA (OR 0.95),PsA (OR 1.19) 或SpA (OR 0.91) 患者,心血管疾病风险增加不再显著.
结论:
- 与健康个体相比,心血管疾病在IA患者中仍然更为普遍.
- 这种高风险在很大程度上受到传统心血管风险因素的更高患病率的影响.
- 加强传统心血管风险因素的识别和管理对于患有RA,PsA和其他IA疾病的患者至关重要.
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