与RA相关的间歇性肺病患者的死亡率增加:来自法国行政卫生保健数据库的数据
Pierre-Antoine Juge1,2, Lidwine Wemeau3, Sebastien Ottaviani4
1INSERM UMR 1152, Université Paris Cité, Paris, Île-de-France, France pierreantoine.juge@aphp.fr.
RMD open
|December 6, 2023
概括
风湿性关节炎相关的间歇性肺病 (RA-ILD) 显著增加死亡率. 年轻的患者,男性,以及先前患有类风湿性关节炎的ILD患者面临的风险最高.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 间歇性肺病 (ILD) 是类风湿性关节炎 (RA) 的严重并发症.
- 了解RA-ILD的死亡因素对于患者管理至关重要.
研究的目的:
- 估计类风湿性关节炎相关间歇性肺病 (RA-ILD) 患者的死亡率.
- 确定影响RA-ILD患者死亡率的特定因素.
主要方法:
- 法国国家医疗保险数据库 (2013-2018) 的分析.
- 包括被诊断患有类风湿性关节炎 (RA) 和ILD的成年患者.
- 在年龄,性别和疾病发病时间方面,RA-ILD患者与没有ILD的RA患者的1:1匹配.
- 考克斯比例危险回归用于比较死亡率.
主要成果:
- 与没有ILD的RA相比,RA-ILD与死亡率增加3.4倍有关.
- 在75岁以下的患者中,死亡风险更高 (HR 4.8),而不是老年患者 (HR 3.0).
- 在RA发作之前出现ILD的患者的死亡风险明显高 (HR 8.4),而在RA发作后出现ILD的患者的死亡风险明显高 (HR 2.9).
- 男性的死亡风险 (HR 5.2) 比女性 (HR 3.6) 高.
结论:
- RA-ILD与类风湿性关节炎患者的死亡率增加有关.
- 年龄较小 (<75岁),在RA之前的ILD和男性性别是RA-ILD中死亡率较高的重要风险因素.
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