细菌癌症疗法使用减弱的适应的Salmonella enterica血清菌Gallinarum
Daejin Lim1, Kwangsoo Kim2,3, Taner Duysak3
1Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Molecular therapy oncolytics
|December 6, 2023
概括
一种新的特定于禽类的沙门氏菌 (Salmonella Gallinarum) 菌株,经过工程改造以减少毒性,有效地向并减少小鼠的瘤. 由于其对鸟类的特异性,这种工程细菌显示出作为一种更安全的抗癌疗法的承诺.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 细菌学 细菌学是一门学科.
背景情况:
- 沙门氏菌 (Salmonella enterica serovar Gallinarum,简称S.Gallinarum) 是一种特定于鸟类的病原体.
- 减弱的沙门氏菌株正在探索癌症治疗,因为它们的瘤定位性质.
- 调节细菌毒性是开发安全有效的活细菌癌症治疗的关键.
研究的目的:
- 开发和评估一种新型的抗癌疗法,使用工程化S. Gallinarum菌株.
- 评估生物发光,ppGpp缺乏的S. Gallinarum (ΔppGpp S. Gallinarum) 的瘤向能力和抗癌疗效.
- 在临床前癌症模型中确定 ΔppGpp S. Gallinarum 的安全性.
主要方法:
- 用于追踪的生物发光 ΔppGpp S. Gallinarum 菌株的构建.
- 静脉注射 ΔppGpp S. Gallinarum 给患有综合性和人类异种移植瘤的小鼠.
- 监测生物发光,组织中的细菌数量和抗癌作用.
主要成果:
- 在注射后2天内,在瘤中特别检测到强烈的生物发光信号.
- 注射后一天,瘤组织中的高细菌数量 (>10^8 CFU/g),正常器官的细菌数量较低.
- 在CT26结肠癌模型中观察到显著的抗癌作用,病毒性降低,允许更高的治疗剂量.
结论:
- 工程S.Gallinarum表明特定的瘤向和显著的抗癌活性.
- 减少 ΔppGpp S. Gallinarum 的毒性提高了安全性,并允许更高的治疗剂量.
- 特定于鸟类的S. Gallinarum为开发更安全的活细菌癌症疗法提供了一个有前途的平台.
相关概念视频
Cancer Vaccines
376
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
376
Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K


