在转化为轻度认知障碍的受试者中,特定的杏仁体子领域的缩
Caterina Padulo1,2, Carlo Sestieri1,3, Miriam Punzi1,4
1Department of Neuroscience, Imaging, and Clinical Sciences University "G. d'Annunzio" of Chieti-Pescara Chieti Italy.
Alzheimer's & dementia (New York, N. Y.)
|December 6, 2023
概括
杏仁体缩,特别是在特定的子领域,是认知能力下降和进展到轻度认知障碍 (MCI) 的早期指标,在患有阿尔茨海默病 (AD) 风险的人群中. 这种结构变化与海马或皮质改变不同,与认知表现相关.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 放射学 放射学是一门学科.
背景情况:
- 已知阿尔茨海默氏病 (AD) 病理影响杏仁体的早期.
- 目前尚不清楚杏仁体子场缩是否有助于从健康认知过渡到轻度认知障碍 (MCI).
研究的目的:
- 调查不同杏仁体子领域的缩是否与从健康认知向MCI的进展有关.
- 为了确定杏仁体的结构变化是否与临床前AD的认知表现相关.
主要方法:
- 对97名认知健康个体 (ADNI-3) 的解剖MRI扫描进行分析,分类为稳定 (s-HC) 或转换为MCI (c-HC).
- 使用概率方法和ex vivo数据,半自动对杏仁体子场进行细分.
- 杏仁体子场体积,整个杏仁体,海马体和皮质厚度与基线和纵向认知测量之间的相关性分析.
主要成果:
- 与稳定对照组 (s-HC) 相比,转换为MCI (c-HC) 的个体表现出右桃体体积减少.
- 特定的杏仁体子场,包括底侧核综合体,前杏仁体区域和过渡区域,在c-HC个体中显示缩.
- 杏仁体子领域的宏观结构变化与48个月的认知表现变化相关,而海马和皮质体积没有显著差异.
结论:
- 这些发现提供了解剖学证据,证明了杏仁体在AD临床前阶段的早期参与.
- 杏仁体子场缩是认知能力下降和MCI进展的潜在生物标志物.
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