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不同的药物可以减少漂白凝对纸组织造成的损伤吗? 一个对基础研究的系统审查
Letícia Aparecida Silva Batista1, Alexandre Henrique Dos Reis-Prado1, Hebertt Gonzaga Dos Santos Chaves1
1Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, MG, Brazil.
Restorative dentistry & endodontics
|December 6, 2023
概括
像生物玻璃和MI Paste Plus这样的局部药物在动物研究中显著减少了来自漂白凝的纸炎症. 某些物质在实验室测试中也降低了细胞毒性,但需要更多的人体研究.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料是一种生物材料.
- 细胞生物学 细胞生物学
背景情况:
- 牙漂白剂,如过氧化 (HP),可以导致纸组织损伤和炎症.
- 识别保护剂对于安全有效的牙漂白程序至关重要.
研究的目的:
- 研究各种局部和全身药物的有效性,以减轻由漂白凝引起的纸组织损伤.
- 综合当前关于降低纸炎症和漂白后细胞毒性的药物的证据.
主要方法:
- 电子数据库的系统审查 (搜索时间为2023年7月),包括体内和体外研究.
- 评估包括动物和实验室研究的偏差风险.
- 用35%-38%的过氧化漂白之前或在漂白期间局部或全身应用的评估剂的研究分析.
主要成果:
- 九项动物研究表明,局部药物如生物玻璃,MI Paste Plus,KF降解敏感剂和奥托斯波林显著降低了HP诱导的脉炎症.
- 在动物模型中,系统性 (口服) 药物并未证明减少肉炎症.
- 十七项体外研究表明,酸,布丁,化和过氧化酶可以降低细胞毒性,尤其是在预先应用时.
结论:
- 局部药物在减少与牙漂白相关的脉炎症和细胞毒性方面表现有前途.
- 需要使用人类纸组织进行进一步的体外和临床研究来证实这些发现并指导临床实践.
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