周神经网络的与年龄相关的升级调节在向耳核投射的下方结膜细胞上,这些细胞投射到耳核
Laila S Almassri1, Andrew P Ohl1, Milena C Iafrate1,2
1Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.
Frontiers in aging neuroscience
|December 6, 2023
概括
周神经网络 (PNs) 越来越多地在老年下结体 (IC) 中结神经元,可能会损害刺激/抑制平衡,并导致与年龄相关的听力损失和时间精度降低.
科学领域:
- 神经科学是一个神经科学.
- 审计系统研究 审计系统研究
- 老龄化和感官丧失的原因
背景情况:
- 衰老会扰乱下 (IC) 中的激发抑制平衡,导致听力损失.
- 与年龄相关的GABAergic神经传递在IC中的变化会影响时间精度,这是presbycusis的标志.
- 围神经网络 (PNs) 调节突触环境和结构性可塑性,影响神经元功能.
研究的目的:
- 研究IC中衰老,周神经网络 (PNs) 和神经元群体之间的关联.
- 为了确定PNS是否随着年龄的增长而在从IC投射到耳核 (CN) 的刺激神经元周围增加.
主要方法:
- 结合Wisteria floribunda聚素 (WFA) 染色用于PNS与逆行通道追踪.
- 在这项研究中使用了三个年龄组的菲舍尔棕色挪威 (FBN) 鼠.
主要成果:
- 由PNs覆盖的IC-CN细胞的比例翻了一番,从年轻老鼠的约10%增加到老老鼠的20%.
- 这种PNS的增加在lemniscal和非lemniscalIC地区均被观察到.
- 在投射到CN的ipsilaterally和contralaterally的IC单元上,PN增加了.
结论:
- 衰老导致IC中激发性投射神经元周围的神经元周围网络形成的增加.
- 增加PNS可能会降低老年IC-CN通路中的结构性可塑性.
- 这些变化可能有助于改变了与年龄相关的听力损失 (presbycusis) 中观察到的刺激/抑制平衡和时间精度降低.
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