关于呼吸机引起的隔膜功能障碍的发病和治疗的研究进展
Jumei Zhang1,2, Jianguo Feng2, Jing Jia2
1Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, 646000, China.
Heliyon
|December 6, 2023
概括
长时间的机械通风会导致呼吸器诱导的隔膜功能障碍 (VIDD),导致肌肉疲软和不良结果. 对VIDD机制和治疗方法的研究对于降低患者负担和医疗保健成本至关重要.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统生理学 呼吸系统生理学
- 病理生理学 病理生理学
背景情况:
- 长时间的控制机械通风 (CMV) 可以诱导隔膜缩和软弱.
- 这种被称为呼吸器诱导的隔膜功能障碍 (VIDD) 的疾病与不良的临床结果有关,包括增加死亡率和长时间的通风.
- 目前缺乏预防和治疗VIDD的临床策略,这凸显了需要进一步研究的需要.
研究的目的:
- 审查呼吸机诱导的隔膜功能障碍 (VIDD) 的分子病变发生.
- 总结最近在VIDD潜在治疗选择方面的进展.
- 强调了解VIDD对于减少机械通风持续时间和医疗负担的临床重要性.
主要方法:
- 审查现有的关于呼吸机诱导的隔膜功能障碍的动物研究.
- 综合有关分子机制的信息,包括氧化应激,蛋白质水解,废弃缩和离子障碍.
- 关于治疗干预的最新发现的汇编.
主要成果:
- 风扇诱导的隔膜功能障碍与氧化应激,增加蛋白质水解,停止使用缩和离子障碍有关.
- 了解这些分子通路是开发有效治疗的关键.
- 目前还没有确定的临床策略可用.
结论:
- 风机诱导的隔膜功能障碍 (VIDD) 是长时间机械通风的严重并发症.
- 对VIDD的分子病原和治疗进行进一步的研究对于临床应用至关重要.
- 有效管理VIDD可以减少机械通风的持续时间,ICU住院和整体医疗费用.
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