在患有先天性心脏病的儿童中非心脏异常
Xianghui Huang1,2, Yuan Gao1,3, Weicheng Chen1,3
1Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China.
Frontiers in cardiovascular medicine
|December 6, 2023
概括
非心脏异常 (NCAs) 在患有先天性心脏缺陷 (CHD) 的中国儿童中很常见. 不同类型的NCA在不同类型的CHD亚型之间存在显著差异,影响了患者管理.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 医学遗传学 医学遗传学
- 发展生物学 发展生物学
背景情况:
- 非心脏异常 (NCAs) 经常与先天性心脏缺陷 (CHD) 并存,影响患者的结果和疾病病因.
- 了解特定人群中NCAs的患病率和模式对于全面护理至关重要.
研究的目的:
- 调查一组被诊断患有先天性心脏缺陷的中国儿童中非心脏异常的患病率和频谱.
- 为了确定特定的先天性心脏缺陷亚型和非心脏异常的发生之间的潜在关联.
主要方法:
- 从2015年1月1日至2019年12月31日期间,从3,788名住院患有心血管疾病的儿童的医疗记录进行了回顾性分析.
- 挖掘冠心病与非心脏形之间的潜在关联规则.
主要成果:
- 在3788名心血管疾病患者中,很大一部分 (23.42%) 呈现NCAs.
- 受影响最常见的系统是中枢神经系统 (34.61%),面结构 (19.39%),泌尿生殖系统 (15.78%) 和肌肉骨系统 (15.56%).
- 与其他心血管疾病亚型相比, septal 缺陷的NCAs发病率较低,而心房间隔膜缺陷 (AVSD) 的NCA百分比较高.
结论:
- 在患有先天性心脏缺陷的中国儿童中,非心脏异常非常普遍.
- 观察到的特定类型的NCAs在各种先天性心脏缺陷亚型之间存在很大差异,需要定制的临床评估和管理策略.
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