在5年乳腺癌幸存者中,身体组成的变化和随后的心血管疾病风险
Ji Soo Kim1, Jihun Song2, Seulggie Choi3
1International Healthcare Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Frontiers in cardiovascular medicine
|December 6, 2023
概括
维持瘦身量和防止乳腺癌幸存者的脂肪增加与心血管疾病 (CVD) 的风险降低有关. 这项研究强调了人体组成.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 心血管疾病 (CVD) 是乳腺癌幸存者死亡的主要原因.
- 在这种患者群体中,身体组成的变化很常见.
- 了解身体成分和心血管疾病风险之间的联系对于幸存者的健康至关重要.
研究的目的:
- 研究乳腺癌幸存者的身体组成变化与随后心血管疾病风险之间的关联.
- 为了确定影响心血管疾病风险的特定身体成分指标.
- 探索身体组成变化和代谢标记之间的关系.
主要方法:
- 一项使用韩国国家医疗保险服务数据库的队列研究.
- 包括73,271名40岁及以上的5年乳腺癌幸存者.
- 应用验证的预测方程和多变量考克斯比例危险回归来评估心血管疾病风险和身体成分变化.
主要成果:
- 持续高的肌肉质量百分比 (LBMP) 和尾骨肌肉质量百分比 (ASMP) 与显著降低心血管疾病风险相关 (32%和40%的降低,分别).
- 持续高的身体脂肪质量百分比 (BFMP) 与心血管疾病风险增加有关.
- 与持续低的BFMP相比,BFMP从低增加到高与更高的心血管疾病风险相关.
结论:
- 保持高的瘦身量和尾骨肌肉质量对乳腺癌幸存者的心血管疾病有保护作用.
- 防止身体脂肪量增加对于减轻心血管疾病风险至关重要.
- 身体组成的变化与代谢标志物的变化相互关联,影响整体心血管健康.
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