红细胞分布宽度及其与死亡率和心脏代谢结果相关的多基因评分
Jingxue Pan1,2, Jiangming Sun2, Isabel Goncalves2
1Division of Child Healthcare, Department of Paediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
红细胞分布宽度 (RDW) 增加预测心血管疾病和死亡率. 然而,对RDW的遗传倾向并不能预测心血管疾病的结果,尽管RDW及其遗传分数都与较低的糖尿病发病率有关.
科学领域:
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
- 代谢疾病 代谢疾病
背景情况:
- 红细胞分布宽度 (RDW) 的增加与各种不良健康结果有关.
- 了解RDW的预后和病因作用,同时考虑表型和遗传因素,对于预测心血管疾病,糖尿病,慢性病 (CKD) 和死亡率至关重要.
研究的目的:
- 研究红细胞分布宽度 (RDW) 水平的预后和病因作用.
- 检查表型RDW和遗传倾向 (RDW的多基因得分 - PGS-RDW) 对心血管结果,糖尿病,CKD和死亡率的预测价值.
主要方法:
- 分析了来自马尔默饮食和癌症研究 (MDCS) 的27,141名中年成年人,平均随访时间为21年.
- 使用血液学分析仪测量RDW,并从遗传数据中构建PGS-RDW.
- 考克斯比例危险回归的应用,以评估RDW,PGS-RDW和各种健康结果之间的关联.
主要成果:
- RDW与中风,心房动,心力衰竭,静脉血栓栓塞,CKD和全因死亡率的增加风险显著相关.
- RDW与糖尿病发病率相反相关.
- 多基因RDW (PGS-RDW) 评分与糖尿病发病率有关,但与心血管结果或死亡率无关.
结论:
- RDW是心血管疾病和死亡率的重要预测因素.
- 基因确定的RDW (PGS-RDW) 与发生的心血管疾病没有显著的关联.
- 现型RDW和PGS-RDW都显示出与糖尿病发病率的反向关联,这表明需要进一步调查的潜在因果关系.
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