马的严重喘与增加的呼吸道内化有关
Laurence Leduc1, Mathilde Leclère1, Laurie Girardot Gauthier2
1Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Journal of veterinary internal medicine
|December 6, 2023
概括
马类喘与呼吸道神经密度增加有关,可能会恶化光滑肌肉重塑和疾病严重程度. 这项研究量化了患有喘的马的周围支气管内置.
科学领域:
- 兽医病理学 兽医病理学
- 马匹呼吸道疾病 马匹呼吸道疾病
- 神经科学是一个神经科学.
背景情况:
- 改变的内接有助于人类喘中的气道过敏反应.
- 在与马类喘相关的空气流量限制中内化作用尚不清楚.
研究的目的:
- 在患有喘的马匹中描述周支气管内.
- 为了测试空气通道内置增加与对照对象相比,喘马的假设.
主要方法:
- 一个盲目的病例对照研究,使用来自8匹患有严重喘的马和8匹健康对照的肺样本.
- 用S100抗体进行免疫组织化学检测,确定了神经.
- 组织形态测量测量了周支柱区域的神经数量和区域,并与呼吸道光滑肌相关联.
主要成果:
- 与对照人群相比,患有喘的马在周围支气管区域的数量和累积神经区域显著增加.
- 呼吸道平滑肌肉内或内神经的数量在患有喘的马中也显著增加.
- 这些发现表明,在马类喘中,呼吸道内接增加.
结论:
- 马类喘与增加的呼吸道内化有关.
- 这种增强的内化可能有助于气道光滑肌肉重塑.
- 增加内化可能会加剧马类喘的严重程度.
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