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同时使用季节性流感和COVID-19 mRNA疫苗

Teresa Aydillo^1,2, Maria Balsera-Manzanero³, Amaya Rojo-Fernandez^1,2

¹Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USA.

Emerging microbes & infections

|December 6, 2023

概括

用季节性流感和mRNACOVID-19疫苗进行双重疫苗接种对整体免疫反应没有显著影响. 支持同时服用,当疫苗在单独的手臂中给予时,对H3N2抗体水平有潜在的益处.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

目前的指导方针建议同时使用季节性流感和COVID-19 mRNA助推疫苗.
在流感和SARS-CoV-2疫苗之间存在抗原干扰的可能性尚不清楚.
了解双重疫苗接种对免疫性影响对于公共卫生战略至关重要.

研究的目的:

评估季节性流感疫苗在与mRNA COVID-19疫苗同时使用时的免疫性.
评估对抗体和细胞免疫反应的潜在干扰影响.
基于在同一或不同的手臂中同时使用的免疫反应进行比较.

主要方法:

128名志愿者参加了22-23日的流感季节.
三组:仅接种流感疫苗,或在同一或不同的手臂中使用双价COVID-19 mRNA疫苗.
血清和全血分析了基线,第7天和第28天的抗体和T细胞反应.

主要成果:

双重疫苗接种时观察到的副作用增加,与已知的mRNA疫苗反应性相一致.
在所有组接种疫苗后4周的高抗体水平.
当COVID-19疫苗在不同的手臂中时,对H3N2病毒的抗体诱导略有增强,特别是在没有先前存在的免疫力的情况下.
在不同组的流感特异性细胞免疫反应中没有显著差异.

结论:

支持同时使用季节性流感和mRNA COVID-19疫苗.
双重疫苗接种不会大大影响疫苗的免疫性.
在单独的臂部注射疫苗可能为H3N2抗体反应提供轻微的优势.

关键词:

在 COVID-19 疫情中,疫苗接种疫苗接种流感流感流感流感流感这是mRNA疫苗.接种季节性疫苗的情况

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