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Updated: Jul 9, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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基于硫烯酸探针的共价PROTAC设计方法

Qinhong Luo1,2,3, Yaqi Wang2, Zhanfeng Hou2

  • 1Department of Pharmacy, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China. wjl06@163.com.

Chemical communications (Cambridge, England)
|December 6, 2023
PubMed
概括

这项研究引入了一种新型的共价蛋白解定位嵌合体 (PROTAC) 策略,该策略使用N-硫烯酸弹头向氨酸残留物. 这种方法可以开发新的向蛋白质降解疗法,特别是针对难以向的蛋白质.

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