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Updated: Jul 9, 2025

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缺氧和矩阵金属蛋白酶13-响应的水凝微球缓解骨关节炎进展在生物体内

Tong Zhou1, Hao Xiong2, Shun-Yu Yao3

  • 1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, China.

Small (Weinheim an der Bergstrasse, Germany)
|December 6, 2023
PubMed
概括

这项研究引入了一种新的低氧反应性水凝微球系统,用于骨关节炎治疗. 该系统有效地提供氧化,并清除活性氧物种,减少炎症和防止软骨破坏.

关键词:
东道主与客人的识别.水凝微球是水凝的微球.低氧反应的反应炎症性微环境是一种炎症微环境.骨关节炎是一种关节炎.

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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