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氧化和ER压力是因胰岛素生物合成和棕酸在胰岛素生成细胞中的增加而产生的

Brenda Vidrio-Huerta1, Thomas Plötz1, Stephan Lortz1

  • 1Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

Journal of molecular endocrinology
|December 6, 2023
PubMed
概括

在早期的2型糖尿病 (T2DM) 中,高胰岛素需求会导致内分泌网膜 (ER) 压力和细胞损伤. 将其与棕酸相结合,会加速功能障碍并触发细胞亡,强调减少胰岛素需求的必要性.

关键词:
催化酶的催化剂是什么细胞内膜网膜的内oplasmic网膜.葡萄糖-脂质毒性 葡萄糖-脂质毒性胰岛素分泌细胞可以分泌胰岛素.棕酸是一种棕酸.蛋白质折叠 蛋白质的折叠有活性氧物种的反应性氧物种.

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