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动物菌 (Bifidobacterium animalis) 的亚种. 乳糖增强新生儿免疫力:解开对沙门氏菌的系统性防御
Chunxiu Lin1,2, Yugui Lin3, Shunhe Wang1,2,4
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, P. R. China. wanggang@jiangnan.edu.cn.
Food & function
|December 6, 2023
概括
早期的益生菌干预与Bifidobacterium animalis亚种. 乳糖改变了新生儿肠道微生物群的形状,增强了对大鼠沙门氏菌感染的系统免疫力和神经发育.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖显示出调节新生儿肠道免疫力和打击沙门氏菌的潜力.
- 关于其对新生儿中枢,外围和神经免疫反应的影响的研究有限.
研究的目的:
- 研究B. animalis亚种的作用和机制. 新生小鼠新生儿乳糖在萨尔摩尼拉感染后的系统性免疫反应.
- 评估其对肠道微生物群,全身免疫和神经发育的影响.
主要方法:
- 新生小鼠接受了B. animalis亚种的预治疗. 产后6小时的乳腺. 产后6小时的乳腺.
- 诱导了沙门氏菌感染,并评估了血液,肝脏,脏和肠道中的细菌流行率.
- 分析了免疫细胞子集,神经发育和神经免疫平衡.
- 进行了血清和结肠的代谢分析.
主要成果:
- B. animalis 亚种 动物类 乳糖的预处理重新塑造了肠道微生物群,特别是Bifidobacterium.
- 在预先治疗的老鼠的多个器官中,沙门氏菌的流行率降低了.
- 改善了T淋巴细胞亚群平衡,在脏和胸腺中得到改善.
- 促进了大脑的神经发育和神经免疫平衡.
- 代谢分析揭示了血清和结肠代谢物之间的相关性,表明微生物群介导的全身影响.
结论:
- B. animalis 亚种 动物类 乳糖前期治疗有效调节新生儿对沙门氏菌感染的系统性免疫反应.
- 益生菌通过改变肠道微生物群的组成和新陈代谢来影响免疫平衡和神经发育.
- 结肠和血清代谢物的协调调节在观察到的全身免疫效应中起着关键作用.
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