COVID-19和肺癌之间的关系
Laura Melocchi1, Maria Cecilia Mengoli2, Giuseppe Bogina3
1Pathology Unit, Services Area, Fondazione Poliambulanza Hospital Institute, Brescia, Italy.
由于COVID-19的流行,肺癌的诊断和查减少了. 然而,检查来自SARS-CoV-2患者的肺癌手术样本揭示了COVID-19早期组织学特征.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19大流行严重扰乱了全球卫生服务,影响了癌症查和诊断.
- 肺癌查率大幅下降 (高达56%),导致许多地区的诊断延迟和晚期呈现.
研究的目的:
- 调查COVID-19大流行对肺癌诊断和治疗的影响.
- 在肺癌手术标本中识别SARS-CoV-2感染的早期组织学特征.
主要方法:
- 肺癌查和诊断率在流行病前和期间的比较分析.
- 从与SARS-CoV-2同时感染的患者手术肺癌样本的组织病理学检查.
主要成果:
- 观察到肺癌查和诊断的全球下降,一些卫生系统减轻了这些影响.
- 肺癌手术样本中早期的SARS-CoV-2感染显示出特征性的组织学变化,包括高塑性肺细胞,纤维素排泄物,炎症透物和缺失氨酸膜.
- 一些卫生系统在早期肺癌中增加了对立体辐射的使用.
结论:
- 在全球范围内,COVID-19流行病对肺癌诊断和护理产生了不利影响.
- 对肺癌手术样本的组织学检查为早期SARS-CoV-2感染模式提供了洞察力.
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