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在德国,黑色素瘤的生存时间更长
Nora Eisemann1, Laura Schumann, Hannah Baltus
1The Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany; The Centre for Cancer Registry Data, Robert Koch-Institute, Berlin, Germany.
Deutsches Arzteblatt international
|December 6, 2023
概括
在过去二十年中,黑色素瘤患者的生存率有了显著的改善,特别是在晚期阶段. 这一积极的趋势与2011年以来新免疫和向疗法的引入相一致.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
背景情况:
- 2011年,针对预后不佳的皮肤黑色素瘤出现了新的治疗方法.
- 免疫疗法和向药物在试验中显示了生存益处.
- 以前缺乏人口水平生存数据.
研究的目的:
- 分析黑色素瘤患者的人口生存趋势.
- 评估新疗法对黑色素瘤存活率的影响.
- 为了识别不同阶段和时间段的生存变化.
主要方法:
- 使用国家癌症登记数据库 (2000-2019).
- 在四个五年期间计算的相对五年生存率 (5YRS).
- 根据性别,年龄和UICC阶段的标准化数据;用于趋势分析的回归模型.
主要成果:
- 包括301,486名患者;整体5YRS从93%增加到95%.
- 在2010年至2014年和2015年至2019年期间观察到显著的生存率增长,特别是在晚期 (UICC IV: 31%至36%).
- 在所有时期 (p < 0.001) 中都发现了统计学上显著的生存率上升趋势 (p < 0.001).
结论:
- 在过去的20年里,黑色素瘤患者的生存率明显改善.
- 最实质性的生存改善发生在最近一段时间的晚期阶段.
- 这些有利的结果与新型治疗选择的出现有关.
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