患者年龄与甲状腺眼病-临床活动评分的关联
Victoria S North1, Henry W Zhou2, Ann Q Tran3
1Department of Ophthalmology, Tufts University Medical Center, Boston, Massachusetts, U.S.A.
Ophthalmic plastic and reconstructive surgery
|December 6, 2023
概括
与年轻人相比,中年患者 (46-70岁) 患有活跃的甲状腺眼病的临床活动得分较高. 这种差异主要是由于老年人群的结膜发红和化学反应增加.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼的自身免疫性疾病.
- 活跃的,未经治疗的TED会出现炎症,并可能导致视力受损.
- 了解人口统计学关联,如年龄,与疾病活动对于患者管理至关重要.
研究的目的:
- 为了研究患者年龄和临床活动评分 (CAS) 在活跃的,未经治疗的甲状腺眼病之间的关联.
- 在TED的演示和严重性中识别与年龄相关的差异.
主要方法:
- 对156名活跃,未经治疗的TED患者 (症状≤9个月) 的回顾性评估.
- 患者分为三个年龄组:18-45,46-70,71-85岁.
- 在不同年龄组中分析了临床活动评分 (CAS1和CAS2) 和特定症状 (红色,化学反应).
主要成果:
- 在46-70岁的年龄组,与18-45岁的年龄组相比,CAS1和CAS2的显著增加.
- 在两次评估访问中,老年患者的结膜发红和化学反应更为普遍.
- 具有较高CAS评分 (4-7) 的患者平均年龄大于具有较低评分 (0-3) 的患者.
结论:
- 中年患者 (46-70岁) 有活跃的,未经治疗的TED显示出更高的疾病活性.
- 与年龄相关的CAS差异受到结膜发红和化学反应的显著影响.
- 这突显了甲状腺眼病的潜在年龄特定管理考虑因素.
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