甲状腺眼病及其与糖尿病相关性:一个主要的综述
Roshmi Gupta1, Pramila Kalra2, Lakshmi B Ramamurthy3
1Orbit, Oculoplasty and Ocular Oncology, Trustwell Hospital, Bengaluru, Karnataka, India.
Ophthalmic plastic and reconstructive surgery
|December 6, 2023
概括
甲状腺眼病 (TED) 和糖尿病 (DM) 分享复杂的相互作用,增加疾病的严重程度和治疗挑战. 管理需要多学科的方法,因为标准的TED治疗不适合患有血糖控制不良的患者.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 经常与糖尿病 (DM) 共同存在,这是已知的危险因素.
- TED和DM之间的相互作用涉及遗传,免疫,细胞,营养和代谢因素.
- 这两种情况都加剧了对方的发病率,影响了患者的整体健康.
研究的目的:
- 审查关于TED和DM之间关系的现有文献.
- 探索TED和DM共同存在的管理挑战.
- 确定潜在的治疗策略及其局限性.
主要方法:
- 在PubMed上使用与TED和DM相关的关键词进行了全面的文献搜索.
- 在2013年至2022年间发表的研究被选为相关性.
- 从93篇选定的文章中提取和分析了数据.
主要成果:
- TED和DM在多个生物层面上相互作用,加剧了每个疾病的影响.
- 患有DM的患者表现出更高的TED频率和严重程度,通常需要视力挽救干预措施.
- 标准的TED治疗,如葡萄糖皮质类药物或teprotumumab可能不适合患有低血糖控制或糖尿病视网膜病变的患者.
结论:
- TED和DM的共存是由共享的病理生理路径驱动的.
- 同时存在的TED和DM的治疗由于疾病严重程度增加和与高血糖和视网膜病变相关的风险带来了挑战.
- 多学科的团队方法对于最佳的TED和DM患者管理至关重要.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Diabetes: Symptoms, Diagnosis, and Complications
554
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
554
Pathophysiology of Diabetes
950
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
950
Glaucoma: Overview
592
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
592
Diabetes: Management and Pharmacotherapy
289
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
289


