系统性炎症对胰腺癌患者对阿纳莫雷林的反应产生不利影响
Masashi Tsunematsu1, Tadashi Uwagawa2, Shinji Onda2
1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tsunematsu@jikei.ac.jp.
概括
在C反应性蛋白 (CRP) - 白蛋白比率 (CAR) 可以预测如果阿纳莫雷林将是无效的晚期胰腺癌患者. 这一发现强调了在治疗前评估炎症状况的重要性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 格林受体激动剂anamorelin在日本已被批准用于胰腺癌治疗.
- 系统性炎症标志物可能会影响治疗疗效.
研究的目的:
- 调查系统性炎症标志物是否预测阿纳莫雷林在晚期胰腺癌中的作用.
- 评估中性细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),淋巴细胞-单细胞比率 (LMR) 和CRP-白蛋白比率 (CAR).
主要方法:
- 分析了31名接受阿纳莫雷林治疗的晚期胰腺癌患者.
- 在治疗前评估了NLR,PLR,LMR和CAR.
- 响应者被定义为3个月后体重增加;非响应者被比较.
主要成果:
- 12名患者 (39%) 没有反应.
- 高水平的CRP和高水平的CAR与没有反应有关.
- 预测CAR≥0.06没有反应 (OR5.6,p=0.032).
结论:
- CRP-白蛋白比率 (CAR) 可以预测在晚期胰腺癌中对阿纳莫雷林的不反应.
- 对炎症状况的全面评估对于治疗规划至关重要.
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