儿童和青少年长期COVID的危险因素:系统性审查和元分析
Daniel G Rayner1, Elaine Wang2, Cloris Su2
1Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada. rayned1@mcmaster.ca.
World journal of pediatrics : WJP
|December 6, 2023
概括
确定儿童和青少年长期COVID的危险因素至关重要. 年龄,肥胖和严重急性COVID-19感染等因素增加了儿科患者长期COVID的风险.
科学领域:
- 儿童传染病 儿童传染病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在儿童和青少年中,COVID-19的长期影响尚不清楚.
- 这项研究的重点是确定长期COVID的风险因素.
研究的目的:
- 系统地审查和元分析与长期COVID相关的危险因素.
- 总结当前关于COVID-19感染后持续症状预测因子的证据.
主要方法:
- 观察性研究的系统审查和元分析 (2020年1月 - 2023年5月).
- 搜索了六个数据库,试验注册表,参考列表和预印服务器.
- 使用随机效应元分析对19个风险因素的合并概率比率;用GRADE评估证据确定性.
主要成果:
- 十六项研究 (N=46,262) 确定了19个分析后的风险因素.
- 与长期COVID相关的风险增加:年龄,过敏性鼻炎,肥胖,先前的呼吸系统疾病,住院治疗,严重急性COVID-19和症状急性COVID-19 (中等确定性).
- 发现女性性别,喘,并发症,心脏病 (风险增加) 和亚裔/黑人种族 (风险降低) 的潜在关联.
结论:
- 已经确定了儿科长期COVID的几种危险因素.
- 需要进一步的研究来了解儿童和青少年长期COVID的病理生理学.
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