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与前列腺癌进展相关的单核酸多态:系统性审查

Daniel Felipe Mendivelso González¹, Santiago Andrés Sánchez Villalobos¹, Andrea Estefanía Ramos¹

¹Cancer Biology Research Group, Instituto Nacional de Cancerología, Bogotá, Colombia.

Cancer investigation

|December 6, 2023

概括

单核酸多态 (SNPs) 显示为前列腺癌 (PCa) 进展的生物标志物具有前景. 这次审查发现了许多与较高或较低风险相关的SNP,有助于PCa管理.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
生物标志物发现发现

背景情况:

前列腺癌 (PCa) 需要改进的生物标志物来准确分类和临床管理.
目前用于预测PCa进展的方法需要改进.
识别新的进展标志物对于患者的治疗结果至关重要.

研究的目的:

系统地审查单核酸多态 (SNP) 与前列腺癌进展之间的关联.
评估SNP作为PCa中的预测生物标志物的潜力.
综合有关影响PCa进展的遗传变异的证据.

主要方法:

2007-2022年主要科学数据库中的出版物的系统审查.
纳入标准:调整后的显著关联,≥24个月的随访,急性前列腺切除术患者,生化复发 (BCR) 数据.
分析了27篇精选的文章,报告了39个基因中的73个SNP.

主要成果:

在七个功能组中,在39个基因中发现了73个单核酸多态 (SNP).
50个SNP与PCa进展风险增加有显著的相关性.
23个SNP与PCa进展风险降低有关,以及四个显著的单元型.

结论:

单核酸多态 (SNP) 是前列腺癌进展的潜在生物标志物.
已识别的SNP可能在PCa的发展和进展中具有功能性作用.
需要进一步的研究来验证这些发现,特别是在不同的人群中,因为大多数变异是在有限的队列中确定的.

关键词:

前列腺新生体前列腺瘤.疾病的进展疾病的进展多形态主义的多态主义.复发性复发性复发性一个单核酸的核酸.

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