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Lacticaseibacillus casei减少长链脂肪酸和大多数物质在肠道粘膜炎的实验模型中.

Stphannie Jamyla de Araújo Barbosa1, Amanda Silveira da Silva2, Maisie Mitchele Barbosa Oliveira3

  • 1Universidade Federal do Rio Grande do Norte - Postgraduate Program in Pharmaceutical Science - Natal (RN), Brazil.

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概括

在接受5 - 甲治疗的小鼠中,口服使用L. casei预防了肠道粘膜炎的损伤. 这种益生菌还减少了便中的特定长链脂肪酸,表明它对肠道健康有保护作用.

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科学领域:

  • 胃肠道学和益生菌研究
  • 化疗诱导毒性的实验模型.

背景情况:

  • 肠道粘膜炎是化疗,特别是5-甲 (5-FU) 的衰弱副作用.
  • 便长链脂肪酸 (LCFA) 的变化可能表明肠道屏障功能障碍.
  • 益生菌,如Lacticaseibacillus casei (L. casei),正在研究它们对减轻化疗引起的副作用的潜力.

研究的目的:

  • 为了研究口服L. casei对5-FU诱导的肠粘膜炎的预防作用.
  • 在L. casei给药后,分析便样本中LCFA和其他化合物的含量.

主要方法:

  • 一个实验模型使用瑞士小鼠接受5 - FU治疗以诱导肠道粘膜炎.
  • 这些组包括负对照组 (盐水),正对照组 (5-FU) 和L. casei治疗组 (L. casei + 5-FU).
  • 便样本使用气色谱质谱法 (GC-MS) 分析LCFA和固醇.
  • 进行了肠道组织的组织病理学分析.

主要成果:

  • L. casei的使用可保存肠粘膜表皮和腺体,减少了对5FU治疗小鼠的缩症状.
  • 便分析显示,在L. casei治疗后,氨酸 (18:2) 和油酸 (18:1) 度显著降低.
  • 在L. casei群体中,杯状细胞数量下降,这表明粘液生产发生了变化.

结论:

  • 预防性口服L. casei有效地预防了5-FU诱导的肠粘膜损伤.
  • L. casei治疗调节了便中的LCFA水平,与其对粘膜炎的保护作用相关.
  • 这些发现凸显了L.casei作为治疗剂的潜力,用于管理化疗引起的胃肠道毒性.