高度部状内皮病变的持续或复发的危险因素
Dulcimary Dias Bittencourt1, Rita Maira Zanine1, Ana Paula Martins Sebastião2
1- Universidade Federal do Paraná, Tocoginecologia - Curitiba - PR - Brasil.
Revista do Colegio Brasileiro de Cirurgioes
|December 6, 2023
概括
阳性宫内膜边缘是宫内皮质瘤在化后复发的唯一预测因素. 其他因素,如病变大小或免疫标志物状态,与疾病持续性没有显著关联.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 宫内皮质瘤 (CIN) 2/3需要治疗,以防止进展为侵袭性宫癌.
- 化程序,包括冷刀化 (CKC) 和循环电术切除 (LEEP),是标准的治疗方法.
- 识别治疗失败的风险因素对于患者管理至关重要.
研究的目的:
- 为了确定结肠镜损伤大小,患者年龄,手术方法,边缘状态或p16/Ki-67表达是否预测CIN持久性或复发.
- 为了确定CIN的化后治疗失败的独立风险因素 2/3.3.
主要方法:
- 一项回顾性观察性研究分析了271名用CKC或LEEP治疗的CIN 2/3患者的数据.
- 评估的变量包括结肠镜损伤大小,年龄,手术技术,手术边缘状态和p16/Ki-67免疫标记表达.
- 使用后勤回归来评估与病变持续或复发的关联.
主要成果:
- 在264名随访患者中,38人经历了持续或复发的CIN.
- 阳性宫内膜边缘被确定为复发的唯一独立风险因素 (p<0.001).
- 没有发现病变大小,年龄,手术类型或p16/Ki-67状态的显著关联.
结论:
- 阳性宫内膜边缘是化后CIN持久性或复发的关键预测因素.
- 对手术边缘的常规评估,特别是宫内边缘,至关重要.
- 病变大小,年龄和免疫标志物状况等因素似乎不会影响这个队列的治疗结果.
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