用于细菌感染成像的抗微生物:巴西报告了第一例病例
Solange Amorim Nogueira1, Marycel Rosa Felisa Figols de Barboza1, Rosemeire Pereira Bezerra1
1Department of Radiology and Diagnostic Imaging, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Einstein (Sao Paulo, Brazil)
|December 6, 2023
概括
-68标有ubiquicidin ((29-41) (68Ga-UBI) 的正子发射断层扫描/计算机断层扫描 (PET/CT) 在体内成功识别了骨髓炎感染的焦点. 这种分子成像方法显示了诊断骨感染的潜力.
科学领域:
- 核医学就是核医学.
- 分子成像学分子成像学
- 放射性药理学 是一种放射性药理学.
背景情况:
- 分子成像提供了工具来区分感染和炎症,并监测治疗.
- -68标有ubiquicidin ((29-41) (68Ga-UBI) 的目标是细菌膜,显示了感染检测的希望.
- 阳位子辐射断层扫描/计算机断层扫描 (PET/CT) 提高了病变的检测.
研究的目的:
- 报告巴西第一个68Ga-UBI PET/CT临床病例.
- 评估68Ga-UBI PET/CT在诊断慢性骨髓炎中的有效性.
主要方法:
- 一名39岁的女性患者怀疑患有慢性骨髓炎,接受了68Ga-UBI PET/CT.
- 扫描的目的是确认左骨骨折和周围组织的感染.
- 用手术样本培养来进行微生物学确认.
主要成果:
- 68Ga-UBI PET/CT显示,在骨骨折部位,固定板和周围软组织中显著吸收放射性追踪剂.
- 在非整合的左偏距骨骨折中也注意到吸收.
- 黄金葡萄球菌通过手术样本培养得到证实.
结论:
- 68Ga-UBI PET/CT成功在患有慢性骨髓炎的患者体内发现了感染焦点.
- 这种非侵入性分子成像模式显示出在诊断骨感染方面临床应用的巨大潜力.
- 这一案例突出显示了巴西首次使用68Ga-UBI PET/CT用于感染成像.
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