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在抑制性ART期间,过渡性CD4+T细胞枯竭减少了人性化小鼠的HIV储备

Lijun Ling1,2,3, Chandrav De1,2,3, Rae Ann Spagnuolo1,2,3

  • 1International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

PLoS pathogens
|December 6, 2023
PubMed
概括

使用抗CD4抗体的过渡性CD4+T细胞枯竭可以显著减少人性化小鼠的潜伏HIV储备. 这种方法虽然不能防止病毒反弹,但提供了一种潜在的策略,可以在抗逆转录病毒治疗期间降低艾滋病毒的持续性.

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