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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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阴离子电离性脂质中位相中的pH依赖性结构转变对于脂质纳米粒子功能至关重要

Julian Philipp1, Aleksandra Dabkowska2, Anita Reiser1

  • 1Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.

Proceedings of the National Academy of Sciences of the United States of America
|December 6, 2023
PubMed
概括

脂质纳米颗粒 (LNP) 中的阴离子可离子脂质 (CIL) 显示了依赖pH的结构变化,影响了mRNA疗法的疗效. 了解这些转变揭示了LNP在提高药物输送的表现中的关键差异.

关键词:
萨克斯 (SAXS) 的时间可离子化脂质的离子化脂质脂质纳米颗粒的使用方法解热性半相相 解热性半相相提供mRNA的交付.

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