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Updated: Jul 9, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Published on: August 23, 2024

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RAD54L2可以计数TOP2-DNA的添加物,从而促进基因组的稳定性

Giuseppina D'Alessandro1,2, David A Morales-Juarez2, Sean L Richards1,2

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

Science advances
|December 6, 2023
PubMed
概括

研究人员发现RAD54-like 2 (RAD54L2) 能够解决拓酶二分离复合体 (TOP2ccs) 的作用. RAD54L2识别了sumoylatedTOP2,促进分辨率和防止DNA双链断裂,提供了新的癌症药物标.

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