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线粒体的代谢灵活性对于CD8+ T细胞抗瘤免疫是至关重要的

Chao Chen1, Hong Zheng1, Edwin M Horwitz1

  • 1Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Science advances
|December 6, 2023
PubMed
概括

蛋白质铁酸酶,线粒体1 (PTPMT1) 对于CD8+ T细胞抗瘤免疫非常重要. 它的缺失会损害葡萄糖代谢,导致T细胞功能障碍和瘤生长的增加.

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