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一个神经应对机制,将压力引起的焦虑与奖励的动机联系起来
Paul M Klenowski1,2, Rubing Zhao-Shea1,2, Timothy G Freels1,2
1Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Science advances
|December 6, 2023
概括
压力会激活大脑中的特定神经元,而应对行为会减少它们的活动. 准这些神经元可能会减轻焦虑和与压力相关的动机.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子生物学分子生物学
背景情况:
- 应对压力包括减少焦虑的行为.
- 连接压力,焦虑和动机的神经机制仍然不清楚.
研究的目的:
- 研究GABAergic神经元在跨细胞核 (IPN) 在压力,焦虑和动机中的作用.
- 确定压力应对行为和压力增强的动机背后的神经回路.
主要方法:
- 在小鼠中利用光遗传学,光纤测量和单细胞测序.
- 在应激暴露期间操纵IPN中的GABAergic神经元活动.
- 评估了类似焦虑的行为和寻求糖糖的动机.
主要成果:
- 急性压力因素会激活小鼠IPN中的GABAergic神经元.
- 应对压力的行为 (理,糖消费) 降低IPNGABAergic神经元活动.
- 沉默IPNGABAergic神经元模仿了应对和减少焦虑.
- 准IPNGABAergic神经元调节了对糖的压力诱导的动机.
结论:
- 压力激活的IPN GABAergic神经元,表达体静止素,驱动有动力的行为.
- 天生的行为和寻求奖励可能会反对IPN神经元激活作为应对压力的机制.
- 这些发现揭示了压力和动机的新的神经通路.
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