第二种和第一种原发性癌症之间的相关性:对900万癌症患者的系统综述和元分析
Xinyu Wang1, Meiyuan Zeng1, Xueming Ju2
1Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
The British journal of surgery
|December 6, 2023
概括
癌症幸存者面临患第二种原发性癌症 (SPC) 的更高风险,这通常与他们的第一个原发性癌症 (FPC) 有关. 这项研究确定了特定的FPC-SPC联系,有助于早期检测和患者护理.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
- 临床研究 临床研究
背景情况:
- 第一次原发性癌症 (FPC) 幸存者患第二次原发性癌症 (SPC) 的风险增加.
- 产品简介的发展可能与FPC密切相关,影响患者的预后.
- 了解这些相关性对于改善患者的治疗结果至关重要.
研究的目的:
- 探索特定的第二原发性癌症 (SPC) 和第一原发性癌症 (FPC) 之间的相关性.
- 根据最初的癌症诊断,识别SPC发展的模式.
- 为癌症幸存者提供有针对性的查和早期诊断策略.
主要方法:
- 在PubMed,EMBASE,Web of Science和PMC进行SPC研究的回顾性文献搜索.
- 从SEER和NHANES数据库收集28个器官部位的SPC发病率数据.
- 对超过960万名FPC患者和677,000名SPC患者的数据进行了元分析.
主要成果:
- 妇科和甲状腺癌经常先于乳腺癌和结直肠癌.
- 头部和部,门和食道癌症经常被肺癌所跟随.
- 膀和阴茎癌与肺癌和前列腺癌的发病率较高有关;56%的尿道癌患者患有膀癌.
结论:
- 确定了特定的FPC-SPC链接,突出了面临风险的人群.
- 建议对已确定的FPC患者进行密切的临床随访和监测.
- 通过针对性查和基于FPC史的干预措施,可以提高SPC的早期诊断.
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