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对宾夕法尼亚大学气味识别测试 (UPSIT) 的最小临床重要差异 (MCID) 的验证

Ashna Mahadev¹, Dorina Kallogjeri¹, Jay F Piccirillo¹

¹Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.

American journal of rhinology & allergy

|December 6, 2023

概括

宾夕法尼亚大学气味识别测试 (UPSIT) 的最小临床重要差异 (MCID) 被验证为4分. 这一发现对于在临床实践中准确测量嗅觉功能的变化至关重要.

科学领域:

嗅觉神经科学是一种神经科学.
临床测量科学临床测量科学

背景情况:

宾夕法尼亚大学的气味识别测试 (UPSIT) 是评估嗅觉功能的标准工具.
确定UPSIT的最小临床重要差异 (MCID) 对于解释结果至关重要,但一直缺乏.
以前对头部创伤患者的研究表明MCID为4,没有详细的方法.

研究的目的:

为了验证MCID的UPSIT在患者经历嗅觉损失由于后病毒状况,鼻炎,或外科手术程序.
为确定嗅觉功能的有意义改善提供可靠的门.

主要方法:

来自五项嗅觉功能研究的前性收集数据的二次分析.
包括COVID-19引起的嗅觉功能障碍的受试者,慢性鼻炎和透视手术.
利用基于分布 (半标准偏差) 和基于 (临床全球印象改善) 的方法来确定MCID.

主要成果:

该研究包括295名受试者,平均基线UPSIT得分为27 (SD 7.5).
基于分布的方法产生了3.75的MCID值 (一半的基线SD) 和2.9 (一半的三角SD).
基于的方法,将UPSIT变化与临床改善相关联,确定了4.0的MCID. 结合两种方法的保守方法证实了MCID为4或更高.

结论:

在未来的研究和临床实践中,应为UPSIT采用4的MCID.
临床医生和研究人员应报告实现这种临床意义上的差异的患者比例.
这种经过验证的MCID增强了UPSIT在各种嗅觉障碍的临床实用性.

关键词:

在MCID中,MCD是MCD.这是一个UPSITUPSITUPSIT.临床上重要的差异.临床上有意义的变化.嗅觉识别嗅觉识别嗅觉识别

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