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探索lncRNA-VEGF轴:癌症检测和治疗的影响

Nahed S Alharthi¹, Maryam Hassan Al-Zahrani², Ali Hazazi³

¹Department of Medical Laboratory, College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudia Arabia.

Pathology, research and practice

|December 6, 2023

概括

长非编码RNAs (lncRNAs) 通过调节血管内皮生长因子 (VEGF) 途径,显著影响癌症进展和耐药性. 了解lncRNA-VEGF相互作用为癌症检测,预后和治疗提供了新的途径.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

癌症是一种复杂的疾病,由遗传和表观遗传变化驱动,多药耐药性构成重大治疗挑战.
长非编码RNAs (lncRNAs) 是生物功能的关键调节者,它们的失调越来越多地与癌症的发展和进展有关.
血管内皮生长因子 (VEGF) 信号通路对于血管生成至关重要,并与各种癌症有关.

研究的目的:

在癌症的背景下,探索lncRNAs和VEGF通路之间的复杂关系.
通过VEGF信号传递,阐明lncRNAs如何影响癌症进展,血管新生,免疫抑制和治疗敏感性.
根据lncRNA-VEGF相互作用来确定潜在的诊断和治疗点.

主要方法:

文献综述和对lncRNAs,VEGF信号传递和癌症现有研究的分析.
检查特定的lncRNAs (例如,NEAT1,PVT1) 和它们在癌症途径中的作用机制.
研究 lncRNA 与下游信号网络 (如 Wnt,p53,AKT) 的相互作用.

主要成果:

LncRNAs可以充当瘤基因或瘤抑制剂,影响癌症的发展和进展.
几种lncRNAs直接调节VEGF级联,影响血管生成和瘤严重程度 (例如,口腔癌中的NEAT1,肺癌中的PVT1).
LncRNAs通过与关键信号通路的相互作用来调节VEGF的产生和血管生成,影响细胞分裂,迁移和治疗反应.

结论:

LncRNA-VEGF通路相互作用为瘤生物学提供了关键的见解,并提供了潜在的治疗策略.
准参与VEGF信号传递的lncRNA可能会导致癌症检测,预后和治疗结果的改善.
对这些复杂相互作用的进一步研究有望为开发新型癌症疗法提供希望.

关键词:

癌症癌症癌症癌症这是一个LncRNARNA.非小细胞肺癌的非小细胞肺癌.在PVT1中,PVT1是PVT1.在VEGF中,VEGF是VEGF.

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