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作为疫苗候选人的四倍基因被删除的伪狂犬病病毒变体的致病性和免疫性

Zicheng Ma1, Chenlong Jiang1, Depeng Liu1

  • 1Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

Veterinary microbiology
|December 6, 2023
PubMed
概括

一种新的四重基因被删除的伪狂犬病病毒 (PRV) 候选疫苗,ZJ01-ΔgI/gE/TK/UL21,显示加强了干扰素诱导和减少了猪仔的病毒分泌,从而提供了对毒性PRV菌株的更好的保护.

关键词:
免疫性 免疫性 免疫性在 PRV 找 PRV.致病性 致病性 致病性UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21 UL21疫苗 疫苗 疫苗 疫苗

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Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...