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Updated: Jul 9, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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针对pyruvate dehydrogenase复合体/pyruvate dehydrogenase kinase (PDC/PDK) 轴,通过基于结构的虚拟查和药理学评估发现强大的PDK抑制剂

Linling Gan1, Ying Yang2, Zizhen Liang2

  • 1Chongqing Engineering Research Center of Pharmaceutical Sciences, School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, PR China.

European journal of medicinal chemistry
|December 6, 2023
PubMed
概括

研究人员发现了一种新化合物,可以抑制酸脱酶激酶 (PDK) 酶,这对癌细胞代谢至关重要. 这种化合物通过减少瘤细胞的增殖和入侵,显示出作为向癌症治疗的前景.

关键词:
这是一种抗癌药物.癌症代谢 癌症代谢皮鲁酸盐脱酶激酶酶是什么

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