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达菲抗原在达菲阴性个体的红色素形成过程中得到表达

Celia Dechavanne¹, Sebastien Dechavanne¹, Jürgen Bosch²

¹Center for Global Health & Disease, Case Western Reserve University, Cleveland, OH, USA.

Cell host & microbe

|December 6, 2023

概括

达菲血型 (Fy) 在Fy阴性个体中表达,与此前的看法相反. 这一发现解释了这些人群中的Plasmodium vivax疟疾易感性,挑战了根除努力.

科学领域:

* 疟疾学和寄生虫学
* 血液学和血液疾病
* 遗传学和基因组学

背景情况:

* 非洲人的杜菲血型 (Fy) 沉默表型传统上与抗生素活疟疾的耐药性有关.
*最近关于达菲阴性个体中P.vivax感染的报道质疑了这一观点,表明不完全的Fy抑制或替代的入侵途径.
* GATA-1单核酸多态性 (SNP) 与达菲阴性有关.

研究的目的:

* 为了研究功能性Duffy抗原在Duffy阴性个体的红细胞和红色素原始体上的表达.
* 确定P.vivax是否可以入侵Duffy阴性个体的红细胞.
* 阐明在患有杜菲静音表型的人群中P.vivax感染背后的机制.

主要方法:

* CD34+细胞在体外分化成红色素原体.
*分析了Duffy抗原表达在红细胞和红细胞前代从骨髓吸收的Duffy阴性个体.
* 开发一种P. vivax.的体外培养系统.
*评估P.vivax侵入Duffy阴性个体的红细胞的情况.

主要成果:

*功能性Duffy抗原 (Fy) 在Duffy阴性个体的红细胞和红细胞原体的表面表达.
* GATA-1 SNP并没有完全废除 Fy 表达式.
*Plasmodium vivax在体外成功地侵入了Duffy阴性个体的红细胞.

结论:

* 达菲抗原表达在具有达菲沉默表型的个体中持续存在,这解释了他们对P. vivax.敏感性的原因.
*这项研究挑战了长期以来人们对达菲阴性种群中完全抗生P.vivax的信念.
*这些发现对P. vivax疟疾根除策略有重大影响,并强调需要修订诊断和控制措施.

关键词:

杜菲的蛋白质是杜菲蛋白质.达菲阴性个体的人.活性菌的入侵性侵袭骨髓骨髓骨髓骨髓骨髓红色腺体的祖先

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