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在Duffy阴性个体中揭示P. vivax入侵途径

Isabelle Bouyssou¹, Sara El Hoss², Cécile Doderer-Lang³

¹Malaria Genetics and Resistance Unit, INSERM U1201, Institut Pasteur, Université Paris Cité, 75015 Paris, France; École Doctorale ED515 "Complexité du Vivant", Sorbonne Université, 75005 Paris, France; Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Université Paris Cité, 75015 Paris, France.

Cell host & microbe

|December 6, 2023

概括

维瓦克斯疟疾可以感染撒哈拉以南非洲的达菲阴性个体. 在发育过程中,Plasmodium vivax merozoites侵入表达达达菲抗原化学因子受体 (DARC) 的红细胞细胞,揭示了一个隐藏的感染储存库.

科学领域:

疟疾学疟疾学
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

维瓦克斯疟疾被认为在撒哈拉以南非洲没有存在,这是由于广泛的杜菲抗原化学因子受体 (DARC) 缺乏.
达菲结合蛋白 (PvDBP) 与DARC的相互作用是Plasmodium vivax merozoite侵入网状细胞的确立途径.
最近在Duffy阴性个体中出现的vivax疟疾病例挑战了目前对Plasmodium vivax入侵机制的理解.

研究的目的:

在Duffy阴性个体中调查Plasmodium vivax潜在的入侵途径.
为了确定达菲阴性红细胞在红状腺分化过程中是否表达DARC.
评估DARC表达的红细胞对Plasmodium vivax merozoite入侵的敏感性.

主要方法:

在达菲阴性红细胞中末端红状腺分化期间对DARC表达的分析.
在实验室中使用Plasmodium vivax merozoites和DARC阳性Duffy阴性红细胞进行入侵测定.
对已报告vivax疟疾病例的Duffy阴性个体的基因型分析.

主要成果:

达菲阴性红细胞的一个子集在末端红细胞分化过程中暂时表达DARC.
无论其来源如何,Plasmodium vivax merozoites都成功地侵入了DARC阳性Duffy阴性红细胞.
达菲阴性个体可能在红色素形成部位内隐藏着沉默的,深层的Plasmodium vivax感染.

结论:

活菌可以通过准DARC表达性红细胞来侵入Duffy阴性个体.
撒哈拉以南非洲的Duffy阴性种群可能代表了活疟疾的重要,低估的储存库.
这一发现对该地区的疟疾控制和诊断有潜在的临床影响.

关键词:

达菲抗原受体对化学因子的受体.达菲的消极性是一种消极性.这是一种活性菌 (Plasmodium vivax).撒哈拉以南非洲地区.红色素质的人类形成.侵入途径的入侵途径疟疾疟疾是一种疾病.

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