一群神经S神经元调节呼吸和兴奋
Christopher Caleb Angelakos1, Kasey S Girven2, Yin Liu3
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Current biology : CB
|December 6, 2023
概括
侧侧侧臂区域 (LPBA) 中的神经S (NPS) 神经元促进清醒,调节呼吸. 激活这些特定的大脑细胞模仿了更广泛的NPS系统激活的影响.
科学领域:
- 神经科学是一个神经科学.
- 睡眠研究 睡眠研究
- 神经内分泌学神经内分泌学
背景情况:
- 神经S (NPS) 促进兴奋,但涉及的特定神经元群体是未知的.
- 侧侧神经区域 (LPBA),周围位置 (peri-locus coeruleus,peri-LC) 和背中侧丘脑 (dorsomedial thalamus,DMT) 含有NPS+神经元.
研究的目的:
- 为了确定NPS+神经元调节兴奋和睡眠-清醒状态的子群.
- 研究LPBA NPS+神经元在唤醒,睡眠和呼吸中的作用.
主要方法:
- 产生Nps-Cre小鼠用于针对性神经元操纵.
- 映射了NPS+神经元集群的大脑范围内的输入和输出.
- 在小鼠中记录了神经元活动和操纵的特定NPS+亚群 (LPBA,peri-LC).
- 对睡眠-清醒状态和呼吸速率的评估影响.
主要成果:
- 所有三个NPS+亚群 (LPBA,peri-LC,DMT) 都显示出与警状态相关的活性.
- LPBA NPS+神经元在清醒之前和REM睡眠期间表现出活动模式,反映了NPS系统效应.
- 激活LPBA NPS+神经元会增加清醒状态,并减少REM睡眠.
- 激活LPBA NPS+神经元,但不是周边LC,增加呼吸速率.
结论:
- 在LPBA中的NPS+神经元是调节呼吸和睡眠和清醒状态的关键亚群.
- LPBA NPS+神经元足以调解NPS系统的兴奋促进作用.
- 这项研究确定了LPBA NPS+神经元在呼吸控制中的新作用.
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