勃起脊柱肌的放射密度的外科变化和肺移植后的死亡率
Yohei Oshima1, Susumu Sato2, Toyofumi F Chen-Yoshikawa3
1Rehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Respiratory medicine
|December 6, 2023
概括
肺移植 (LTx) 后勃起脊柱肌 (ESM) 密度下降与较差的生存率有关. 在LTx后保持肌肉密度可能会改善患者的治疗结果.
科学领域:
- 医学 医学 医学 医学 医学
- 放射学 放射学是一门学科.
- 胸部外科手术 胸部外科手术
背景情况:
- 勃起脊柱肌 (ESM) 的放射密度通常会在肺移植 (LTx) 后降低.
- 这种早期LTx后ESM密度变化的预后意义仍然不清楚.
研究的目的:
- 为了确定早期LTx后期ESM放射密度的降低是否与患者不良预后有关.
- 为了研究在LTx之后ESM放射密度变化的预后影响.
主要方法:
- 对151名接受初级LTx.治疗的成年患者进行了回顾性队列研究.
- 使用胸部CT扫描在LTx前和12周后进行ESM放射密度 (ESMct) 的定量评估.
- 考克斯比例危险回归分析,以评估降低ESMct和整体存活时间 (OS) 之间的关联.
主要成果:
- 总共分析了151名接受者,随访时间中位数为4.4年,死亡人数为39人 (26%).
- 术后ESMct降低显著与较差的OS相关 (HR1.64;P=0.008),即使在多变量调整后.
- 这种关联在尸体LTx接受者中仍然显著.
结论:
- 减少外科手术期间的ESMct,包括低的外科手术前密度,强烈预测LTx后的预后不佳.
- 保持术后肌肉放射密度,反映肌肉质量,对于改善LTx结果至关重要.
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