维罗尼卡·林纳里福利亚亚种 (Veronica linariifolia) dilatata通过EGFR/Akt/ZO-1通路减轻内皮细胞屏障功能障碍来改善LPS诱导的急性肺损伤
Huayan Wu1, Longlong Wu2, Wenchao Yu2
1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Journal of ethnopharmacology
|December 6, 2023
概括
舒曼金 (SMJ) 通过加强内皮屏障,防止急性肺损伤 (ALI). 这种传统中医药可提高EGFR,Akt和ZO-1的调节,为ALI提供了有前途的治疗选择.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
背景情况:
- 维罗尼卡·林纳里福利亚亚种 (Veronica linariifolia) 扩张 (纳卡伊和基塔格.) D.Y.Hong,也称为Shui Man Jing (SMJ),是一种用于治疗呼吸道疾病的传统中医药.
- 它在治疗急性肺损伤 (ALI) 的有效性仍然未被探索.
研究的目的:
- 评估SMJ在急性肺损伤 (ALI) 的治疗潜力.
- 通过EGFR/Akt/ZO-1通路调查SMJ在缓解内皮屏障功能障碍方面的机制.
主要方法:
- 建立了LPS诱导的ALI的体内小鼠模型.
- 通过组织病理学,细胞因子分析和屏障完整性测量来评估SMJ的影响.
- 网络药理学预测了机制,并通过RT-PCR,西部斑点和分子对接来验证.
主要成果:
- SMJ的使用改善了肺组织损伤,并减少了LPS诱导的ALI中的炎症标志物.
- 在体内和体外,SMJ抑制了内皮壁障碍功能障碍.
- SMJ上调了EGFR表达,增加了Akt酸化和ZO-1水平.
结论:
- 在LPS诱导的ALI中,SMJ减轻了血管内皮屏障功能障碍.
- 保护作用通过EGFR/Akt/ZO-1通路进行介导.
- SMJ显示出作为ALI的新型治疗剂的潜力.
相关概念视频
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
170
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
170
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K