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Updated: Jul 9, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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药物查发现阿尔多减少酶是治疗西斯普拉丁引起的听力损失的新目标

Yaqi Liao1, Huanyu Mao1, Xian Gao1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230031, PR China; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai, 200031, PR China; ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, PR China.

Free radical biology & medicine
|December 6, 2023
PubMed
概括

西斯普拉丁因增加阿尔多减少酶活性而导致听力损失. 用Tiliroside或Epalrestat抑制这种酶可以保护听力,从而揭示了化疗诱导的耳毒性治疗的新标.

关键词:
阿尔多斯减少酶的使用黄类化合物 黄类化合物听力损失 听力损失高通量选的高通量选耳部毒性药物 耳部毒性药物氧化应激是一种氧化应激.

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