在固体癌症的新辅助环境中,与癌症相关的纤维细胞
Yanan Gu1, Qiangda Chen2, Hanlin Yin2
1Department of Radiology, Zhongshan Hospital and Shanghai Institute of Medical Imaging, Fudan University, Shanghai 200032, China; Department of Interventional Radiology, Zhongshan Hospital Fudan University Shanghai, 200032, China.
Critical reviews in oncology/hematology
|December 6, 2023
概括
本综述探讨了瘤微环境 (TME) 中的与癌症相关的纤维细胞 (CAF). 它强调了新辅助疗法如何影响CAF,并提出了针对这些细胞的新策略,以提高癌症治疗效率.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫治疗是一种免疫疗法.
背景情况:
- 瘤微环境 (TME) 对癌症的进展和治疗反应至关重要.
- 癌症相关纤维细胞 (CAF) 是TME的关键组成部分,影响瘤生长和治疗耐药性.
- 在初级治疗之前进行的新辅助疗法可以调节TME.
研究的目的:
- 在TME中审查CAF的异质性和相互作用.
- 检查新辅助疗法对CAF和TME的特定影响.
- 提出针对CAF的新型治疗策略.
主要方法:
- 文献综述侧重于与癌症相关的纤维细胞和新辅助疗法.
- 分析CAF异质性及其在瘤进展中的作用.
- 通过新辅助疗法对TME调制的当前知识的综合.
主要成果:
- CAFs通过产生免疫细胞透和药物输送阻碍的细胞外基质 (ECM) 来促进瘤进展.
- 新辅助疗法可以改变TME内的CAF群体和功能.
- 准CAF是一个有希望的策略,可以降低树叶密度并提高治疗效果.
结论:
- 了解CAF异质性及其相互作用对于开发有效的癌症疗法至关重要.
- 新辅助疗法对CAF的影响需要进一步研究以优化治疗方案.
- 针对CAF提供了一个潜在的途径来克服治疗耐药性并改善患者的治疗结果.
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