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海马运动记忆网络的重组取决于熟悉程度,而不是时间
D Gregory Sullens1, Phuoc Nguyen1,2, Kayla Gilley1,3
1Department of Psychology and Neuroscience, Baylor University, Waco, Texas 76798, USA.
Learning & memory (Cold Spring Harbor, N.Y.)
|December 6, 2023
概括
海马参与提取远程运动记忆,即使是对于非事件性任务. 这表明记忆网络随着时间的推移与实践进行重组.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 运动学习是指运动学习.
背景情况:
- 随着时间的推移,记忆网络的重组是有争议的,特别是对于像运动记忆这样的非事件性任务.
- 了解程序性运动记忆网络如何随时间和实践而变化,对于记忆研究至关重要.
研究的目的:
- 为了研究涉及运动记忆的脑网络的依赖时间的重组.
- 为了确定海马是否从事远程,非插曲性运动记忆的检索.
主要方法:
- 在一条直径小迷宫里,小鼠接受了运动训练.
- 实验组包括最近 (1天),持续训练 (20天) 和远程 (20天后训练) 检索.
- 区域c-Fos表达被评估以测量神经活动.
主要成果:
- 在远程运动任务检索过程中观察到海马c-Fos表达的升高.
- 持续训练并没有导致海马c-Fos表达的增加.
- 这些发现表明,海马体仍然参与检索远程运动记忆.
结论:
- 海马在提取远程程序性运动记忆方面发挥着作用.
- 运动记忆网络经历时间依赖的转变,海马体显示远程回忆的参与.
- 这挑战了海马只参与情节性记忆的观念.
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