全手和区域骨矿物质密度参与了类风湿性关节炎
María Lorena Brance1, Agustín Razzini2, Bernardo A Pons-Estel3
1Reumatología y Enfermedades Óseas, Rosario, Argentina; Laboratorio de Biología Ósea, Universidad Nacional de Rosario, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
Reumatologia clinica
|December 6, 2023
概括
与健康人相比,类风湿性关节炎患者的手和腰椎骨密度明显较低. 使用DXA进行手部骨密度测量是一种可重复的方法,用于评估类风湿性关节炎的骨质损失.
科学领域:
- 类风湿病学 类风湿病学
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是指放射学
背景情况:
- 风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节炎症,形,残疾和骨质疏松症.
- 骨矿物质密度 (BMD) 评估对于管理RA并发症至关重要.
- 有限的数据存在于RA患者的手部特异性BMD.
研究的目的:
- 为了评估全手和区域骨矿物质密度 (BMD) 在类风湿性关节炎 (RA) 患者与对照.
- 为了在健康个体中比较主导与非主导手部骨质量.
- 评估腰椎骨干BMD与手部BMD之间的相关性.
主要方法:
- 双能X射线吸收计 (DXA) 用于测量BMD.
- 测量包括腰椎 (LS),整个手和特定的手部区域 (手,手下手,手环).
- 包括成人RA患者和年龄,性别和BMI匹配的对照.
主要成果:
- 与对照人群相比,RA患者在LS,主导整个手,骨,甲骨和手环中表现出明显较低的BMD.
- 非主导手手的骨质量在RA患者中也显著降低,在手腕下部和手环上.
- 在LSBMD和全手BMD之间观察到正相关性 (主导r=0.63,非主导r=0.67).
结论:
- 在RA患者中,手部BMD显著降低,与腰椎BMD相关.
- 测量全手和区域骨质量的DXA测量是一种可重复的方法,用于评估RA的骨损失.
- 在健康受试者中,主导的手骨矿物质密度 (BMD) 在骨和甲骨中高于非主导手.
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