在SARS-CoV-2 BA.2.86亚变体的进化和中和逃脱中
Khadija Khan1,2, Gila Lustig3, Cornelius Römer4,5
1Africa Health Research Institute, Durban, South Africa.
Nature communications
|December 6, 2023
概括
奥米克朗BA.2.86亚变体显示显著突变,但类似的抗体逃到当前变体. 这种SARS-CoV-2菌株可能在南非进化,表现出广泛的免疫逃脱旧免疫力.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 基因组流行病学 基因组流行病学
背景情况:
- 奥米克朗BA.2.86亚型具有超过30种尖端蛋白突变,与之前的SARS-CoV-2变种区分开来.
- 了解BA.2.86的免疫逃脱和复制对于公共卫生战略至关重要.
研究的目的:
- 为了隔离和描述活的Omicron BA.2.86亚变体.
- 评估其中和逃脱抗体和病毒复制能力.
主要方法:
- 从诊断抽样中分离活体BA.2.86.
- 测试抗体中和逃脱的测试,使用来自不同种群和感染史的血清.
- 在细胞培养模型中评估病毒复制动态 (VeroE6-TMPRSS2和H1299-ACE2).
主要成果:
- BA.2.86证明了与Omicron XBB.1.5相似的抗体逃脱,可以抵御XBB家族感染和最近南非血清的免疫力.
- 与祖先的SARS-CoV-2和Omicron BA.1相比,观察到显著的免疫逃脱与特定的血清.
- BA.2.86和XBB.1.5在测试的细胞系中表现出类似的复制动态.
结论:
- 与目前流通的XBB.1.5.5等变种相比,Omicron BA.2.86的抗体逃逸没有显著增加.
- 该亚变种可能在南非演化,发展出与最近的SARS-CoV-2菌株相似的免疫逃脱.
- 需要进一步的监测,以了解BA.2.86.6的进化轨迹和影响.
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