在SARS-CoV-2感染中非编码RNAs的表达:病变发生,临床意义和治疗点
Xiaoxing Liu1, Wandi Xiong2,3, Maosen Ye4
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 100191, Beijing, China.
Signal transduction and targeted therapy
|December 6, 2023
概括
宿主非编码RNAs (ncRNAs) 在COVID-19中发生变化,影响疾病进展和器官损伤. 了解这些ncRNA为2019年冠状病毒疾病的新诊断生物标志物和治疗策略提供了潜力.
科学领域:
- 分子生物学分子生物学
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 随着COVID-19的爆发,人们越来越需要先进的诊断和治疗.
- 主体非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),都与SARS-CoV-2感染有关.
研究的目的:
- 审查宿主ncRNA表达和功能在COVID-19病变发生过程中.
- 探索ncRNAs作为COVID-19分层,预后和治疗反应的生物标志物.
- 讨论针对COVID-19的基于ncRNA的治疗策略.
主要方法:
- 在COVID-19中对宿主ncRNA变化的综合文献综述.
- 分析ncRNA在病毒入侵,复制,免疫反应和多器官损伤中的作用.
- 对ncRNA-COVID-19相互作用的生物信息分析.
主要成果:
- 异常表达的miRNAs, lncRNAs和circRNAs与COVID-19有关.
- ncRNAs参与病毒感染,免疫反应和系统性并发症,包括长期COVID.
- 几种宿主ncRNA显示为COVID-19管理的临床生物标志物具有前途.
结论:
- 主体ncRNAs在COVID-19病原和进展中发挥着关键作用.
- ncRNAs代表患者分层和预后的潜在生物标志物.
- 准ncRNAs为新型COVID-19疗法提供了一个有希望的途径.
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